SGT-263 (5F-CUMYL-P7AICA)

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What is SGT-263 (5F-CUMYL-P7AICA) ?

Buy SGT-263 (5F-CUMYL-P7AICA) is an analytical reference material that is structurally categorized as a synthetic cannabinoid. The physiological and toxicological properties of this compound are not known. 5-fluoro CUMYL-P7AICA is regulated as a Schedule I compound in the United States. This product is intended for forensic and research applications.

Buy SGT-263 (5F-CUMYL-P7AICA) is a pyrrolo[2,3-b]pyridine-3-carboxamide based synthetic cannabinoid that has been sold as a designer drug.It was first identified by the EMCDDA in February 2015.

Pharmacology

Synthetic cannabinoids are a group of new psychoactive compounds (NPS) that act as agonists at the cannabinoid receptor. First reported in 2008, they currently represent one of the largest groups of NPS that are monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Five samples (4 from the European RESPONSE project and one from daily casework) containing different synthetic cannabinoids were analyzed by a complex of analytical methods including gas chromatography–electron ionization mass spectrometry (GC–EI-MS), liquid chromatography–high resolution mass spectrometry (LC–HRMS), infrared spectroscopy (IR) and nuclear magnetic resonance spectroscopy (NMR).

Five new synthetic cannabinoids containing a cumyl moiety as a linked group were identified: CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA, CUMYL-4CN-B7AICA. 5F-CUMYL-PINACA and 5F-CUMYL-P7AICA as well as CUMYL-4CN-BINACA and CUMYL-4CN-B7AICA are constitutional isomers and only differ in the position of a nitrogen atom.

The article contains all analytical data for a proper identification and differentiation of the five cumyl compounds.Synthetic cannabinoid receptor agonists (SCRAs) are a dynamic class of new psychoactive substances (NPS), with novel chemotypes emerging each year. Following the putative detection Buy SGT-263 (5F-CUMYL-P7AICA) in Australia in 2016, the scaffold-hopping SCRAs 5F-CUMYL-PICA, 5F-CUMYL-PINACA, and SGT-263 (5F-CUMYL-P7AICA) were synthesized and characterized by nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-quadrupole time-of-flight-MS (LC-QTOF-MS).

Since little is known of the pharmacology of 7-azaindole SCRAs like 5F-CUMYL-P7AICA, the binding affinities and functional activities of all compounds at cannabinoid type 1 and type 2 receptors (CB1 and CB2 , respectively) were assessed using tritiated radioligand competition experiments and fluorescence-based plate reader membrane potential assays.

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